Cognitive & Mood
Semax
Formula
- Size
- 5mg
Specifications
Semax Technical Profile
OVERVIEW
What Is Semax Peptide?
Semax is a synthetic heptapeptide developed at the Institute of Molecular Genetics of the Russian Academy of Sciences as a stabilized analog of the adrenocorticotropic hormone (ACTH) fragment spanning residues 4 through 10. The semax peptide incorporates a Pro-Gly-Pro C-terminal extension to the native ACTH(4-10) sequence (Met-Glu-His-Phe), providing enhanced stability against enzymatic degradation while preserving and extending the neurotrophic properties of the parent fragment.
As a semax research peptide, this compound has been studied across numerous domains of neuroscience, with particular emphasis on neurotrophic factor expression, cognitive function pathways, and neuroprotective mechanisms. Semax BDNF research has been especially prolific, with multiple published studies documenting the peptide's influence on brain-derived neurotrophic factor and related signaling cascades. Semax nootropic research and semax cognitive research have positioned this compound as a key tool for laboratories investigating neural plasticity and neurodevelopmental biology. Researchers who buy semax from VivePeptides receive ≥99% purity from a trusted USA supplier.
- 01
ACTH(4-10) Analog
Synthetic heptapeptide with neurotrophic and cognitive research applications
- 02
≥99% HPLC Purity
Every batch verified via high-performance liquid chromatography
- 03
USA Tested & Verified
Third-party analytical testing performed in USA laboratories
RESEARCH
Semax Mechanism of Action in Research
The semax mechanism of action centers on neurotrophic factor modulation and neuropeptide signaling pathways. Semax research has revealed that this peptide influences brain function through multiple converging mechanisms distinct from classical ACTH-mediated effects.
BDNF and Neurotrophic Factor Upregulation
Semax BDNF research represents one of the most documented aspects of its mechanism. Studies indicate that semax may significantly upregulate brain-derived neurotrophic factor (BDNF) expression in multiple brain regions, including the hippocampus, cortex, and basal forebrain. Published research demonstrates that semax's effects on BDNF signaling extend to downstream TrkB receptor activation and related intracellular cascades involved in synaptic plasticity and neuronal survival (Dolotov et al., Neuroscience, 2006).
Melanocortin System Interactions
As an ACTH fragment analog, semax research has explored its interactions with the melanocortin receptor system. While semax lacks the classical adrenocorticotropic activity of full-length ACTH, studies suggest it may interact with melanocortin receptor subtypes (particularly MC4R) in brain regions involved in cognition and neural development. These interactions represent a distinct pathway through which semax may influence neural function.
Neuroprotective Gene Expression
Semax cognitive research has identified broad effects on gene expression in neural tissue. Published studies indicate that semax may modulate the expression of genes involved in neuroprotection, anti-apoptotic pathways, and inflammatory regulation in the central nervous system. Genome-wide expression analyses have documented changes in hundreds of genes following semax administration in research models. ---
COMPARISON
Semax vs Selank: Research Peptide Comparison
Semax
Semax and selank are complementary nootropic research peptides with distinct pharmacological profiles. This comparison helps researchers choose the appropriate compound for specific experimental questions.
Selank
Both semax and selank are available from VivePeptides at ≥99% purity. Researchers studying neurotrophic factor biology and cognitive pathways typically choose semax, while those investigating anxiolytic mechanisms and neuro-immune interactions may prefer selank.
| Feature | Semax | Selank |
|---|---|---|
| Origin | ACTH(4-10) analog | Tuftsin analog (IgG fragment-derived) |
| CAS Number | 80714-61-0 | 129954-34-3 |
| Amino Acids | 7 | 7 |
| Molecular Weight | 813.93 Da | 751.87 Da |
| Primary Research Focus | Neurotrophic/cognitive research | Anxiolytic/immunomodulatory research |
| Key Pathway | BDNF/TrkB signaling | GABAergic system modulation |
| Parent Peptide | ACTH(4-10) | Tuftsin (Thr-Lys-Pro-Arg) |
| Immune Effects | Limited | Well-documented immunomodulatory activity |
RESEARCH STUDIES
Semax Research Applications & Published Studies
Semax research encompasses a substantial body of published preclinical literature, with studies spanning neurotrophic biology, cognitive function, and neuroprotection.
BDNF and Neurotrophic Factor Studies
Dolotov et al. (Neuroscience, 2006) published foundational semax BDNF research documenting the peptide's effects on BDNF mRNA expression in rat brain tissue. Additional studies have shown that semax increases NGF (nerve growth factor) and GDNF (glial cell-derived neurotrophic factor) levels in specific brain regions. These neurotrophic factor studies form the cornerstone of semax cognitive research.
Cognitive and Behavioral Research
Published semax research includes multiple behavioral studies using established cognitive paradigms. Studies using the Morris water maze, passive avoidance, and novel object recognition tests in rodent models have documented measurable effects on learning and memory-related behaviors following semax administration. These findings support semax's classification as a nootropic research peptide.
Neuroprotection Research Models
Semax research has extended to neuroprotection models, including studies of cerebral ischemia, oxidative stress, and neurotoxicity in animal models. Gusev et al. (Doklady Biological Sciences, 2005) published findings on semax in cerebral ischemia models, while additional studies have examined its effects on gene expression patterns following neural insult in research settings.
QUALITY ASSURANCE
Quality & Testing Standards
HPLC & Mass Spectrometry
Every semax batch undergoes HPLC and mass spectrometry analysis to confirm peptide identity, sequence accuracy, and purity.
Third-Party Verified
All semax is independently tested at third-party USA-based analytical laboratories.
≥99% Purity Standard
VivePeptides semax consistently meets or exceeds ≥99% purity for reliable, reproducible research results.
FAQ
Frequently Asked Questions About Semax
What is semax used for in research?
What purity is VivePeptides semax?
How should semax be stored?
What is the relationship between semax and ACTH?
Is VivePeptides semax third-party tested?
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Semax
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